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Reconstitution best practices for lyophilized GHK-Cu include: Sterile technique use bacteriostatic water or sterile 0.9% saline

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However, decreased responsiveness to VIM DBS by select body parts (possibly due to the somatotopic organization of the VIM nucleus) increased tolerance to VIM stimulation due to compensation or disease progression [176, 177], and the development of adverse side effects, such as dysarthia and dysphagia [174], in patients, has driven efforts to optimize DBS targeting