Together, these compounds enhance the bodys ability to metabolize fat, promote detoxification, and sustain energy levels throughout the day
The four most common GLP-1s cost around $1,000 a month if you dont have insurance or use a savings plan
Head-to-Head Comparison: Key Metrics Semaglutide: MW 4113.58 Da | Selective GLP-1 RA | Injectable (weekly) or oral (daily with SNAC) | Mean weight loss 14.9% (STEP 1) | FDA-approved 2021 (obesity) Tirzepatide: MW ~4813.45 Da | Dual GLP-1/GIP | Injectable (weekly) | Mean weight loss 22.5% (SURMOUNT-1) | FDA-approved 2023 (obesity) Retatrutide: MW ~4500 Da | Triple GLP-1/GIP/Glucagon | Injectable (weekly) | Mean weight loss 28.7% (TRIUMPH-4 Phase 3) | Phase 3 as of 2026 Orforglipron: MW 541.65 Da | Selective GLP-1 (non-peptide) | Oral (daily, no food restriction) | Mean weight loss ~14.7% (Phase 3) | FDA-approved April 2026 Receptor Selectivity and Mechanism Differences The four compounds represent a spectrum from single-target to multi-target pharmacology
Otherwise, you may get unpleasant side effects like nausea, vomiting, and stomach pain
At House of Aesthetix, we approach wellness from every angle, combining internal balance with outward confidence
Braak H, Ghebremedhin E, Rb U, Bratzke H, Del Tredici K