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On the other hand, causation cannot exist without association, and multiple independent associations coupled with other lines of independent evidence support causation

endocrine pathway involving enteroendocrine signaling stimulated by bacterial byproducts and hypothalamic-pituitary-adrenal (HPA) axis activation modulating the gut microbiota

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ChiuCALuLFYuTHHungWCChungFMTsaiITet alIncreased levels of total P-Cresylsulphate and indoxyl sulphate are associated with coronary artery disease in patients with diabetic nephropathy

Its presence broadens the blend further, but it also adds another variable that researchers must consider when interpreting a multi-component formulation