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When used as part of CagriSema, the dosing schedule looked like this in trials: Weeks 04: 0.25 mg cagrilintide + 0.25 mg semaglutide Weeks 48: 0.5 mg + 0.5 mg Weeks 812: 1 mg + 1 mg Weeks 1216: 1.7 mg + 1.7 mg Week 16 onward: 2.4 mg + 2.4 mg (full maintenance dose) Until the medication is approved and prescribing information is finalized, any dosing decisions would only happen through participation in a clinical trial or, eventually, under the guidance of a healthcare provider

Among various cell surface receptors, IGF-1R (insulin-like growth factor receptor) expression is important for myoblast proliferation and maintenance of normal muscle mass 21,22,23,24,25,26

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On the other hand, as described later, GHR signaling has been shown to have growth promoting effects independent of IGF-1