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Titration typically involves four to five dose steps over 16 to 20 weeks, with each step building on your previous tolerance

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60,61,62 RNase H-dependent ASOs, such as gapmers, bind to complementary mRNA, recruit RNase H to cleave mRNA, and thus block translation of the target gene

Any muscle loss can be detrimental, as it is metabolically active and contributes to many physiological processes