Diarrhea: Diarrhea is another common gastrointestinal issue
A separate 2025 trial in NEJM Evidence (Shah et al.) in adults with T1D and obesity on AID found that around one in three semaglutide-treated participants met a combined goal of improved time in range, low hypoglycemia, and at least 5% weight loss
For example, switching where the shot is given can help avoid irritation
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Diabetes 49 , 20942101 (2000)
At one year, the treated group had significantly better disease-activity change scores and less pain