The SURMOUNT trials have demonstrated tirzepatide glucose-lowering efficacy, weight loss efficacy, and cardiovascular safety in various patient populations
air objective) on a Leica SP5 Tandem Scanner Spectral 2-Photon confocal microscope (Leica Microsystems, Inc., Buffalo Grove, IL) in The University of Chicagos Imaging Core
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Both are GLP-1 agonists and both impair thermoregulation, but Mounjaro (tirzepatide) is a dual GIP/GLP-1 receptor agonist, meaning it hits an additional metabolic pathway
In detail, GLP-1 treatment leads to a decrease in M1 markers, including IL-6, TNF-, and inducible NOS ( i NOS), while promoting increased levels of markers of M2 such as IL-10, arginase-1(Arg-1), macrophage galectin-1 (MGL-1), and mannose receptor-1 (MRC-1) in murine RAW264.7 macrophages [14, 79]
