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Many patients report reaching their lowest weight around months 46 of consistent therapy

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Results of a multi-centre patient survey

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Glutamate excitotoxicity disrupts synaptic transmission and increases intracellular calcium levels, triggering a cascade of neurotoxic effects

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Most patients experience appetite reduction within 2-4 weeks of starting tirzepatide therapy, with measurable weight loss appearing by 4-8 weeks

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The pharmacological pathway doesn't change based on initial body composition

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