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PMID: 74 KhoiC

Studies focus on receptor affinity, binding kinetics, and activation profiles

While the origins of the observed differences between mice and humans with respect to the l-carnitineBBTMATMAO pathway are not clear, the fact that the second reaction in the conversion of l-carnitine into TMA (i.e., BBTMA) showed marked induction with dietary exposure in subjects likely plays a major role in the observed differences

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doi: 10.1210/jcem.74.6.1375600 35 ChenJWHojlundKBeck-NielsenHSandahl ChristiansenJOrskovHFrystykJ

Akkermansia muciniphila produces propionate and a protein called P9, both of which induce GLP-1 secretion