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1.1 Development of thyroid autoimmunity Under physiological conditions, central immune tolerance eliminates or inactivates T cells that recognize self-antigens within the thymus

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[2] For this reason, elevated serum homocysteine over 15 micromol/L and methylmalonic acid (MMA) over 0.271 micromol/L are considered better indicators of B 12 deficiency, rather than relying only on the concentration of B 12 in blood

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