A multicenter, 16-week, double-blind, placebo-controlled study in children and adolescents with PWS and obesity found that liraglutide had no impact on BMI in children or adolescents after 16 weeks of treatment, nor was weight improved after 52 weeks on the drug compared to placebo
Patients who experience gastrointestinal side effects may require slower dose escalation, which delays reaching therapeutic doses but does not prevent eventual weight loss success
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Regarding cardiovascular parameters , clinical trials have consistently observed modest increases in resting heart rate with GLP-1 receptor agonists, typically in the range of 24 beats per minute
This was not a singular effort by just the biopharmaceutical industry
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