Med Sci Monit 11: BR397-BR404
The recovery of E GSH [matrix] under these conditions likely relies on the efficient removal of GSSG (i.e., by reduction or export from the matrix), and not the import of GSH from the IMS/cytosol since extremely large amounts of GSH had to be imported to balance the GSSG and reach steadystate E GSH [matrix]
Du XL, Edelstein D, Rossetti L, Fantus IG, Goldberg H, Ziyadeh F, et al
According to the Breakthrough Prize committee, these five scientists' complementary contributions from basic hormone discovery through physiological understanding to pharmaceutical development have led to highly effective drugs for diabetes and obesity, ushering in a new era of GLP-1 medicines for cardiometabolic disorders
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