GLP-1 drugs such as Ozempic mimic a natural hormone called GLP-1
PMID: 24022442
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Sushovan Guha, MD, MA, PhD, FASGE, AGAF, is a Houston-based gastroenterologist and hepatologist at Houston Regional Gastroenterology Institute with extensive academic experience, specializing in general GI care, colorectal cancer prevention, and advanced endoscopic procedures.
Mice with knockin of the L973F-IR show similar alterations in signaling in vivo, and this leads to impaired insulin sensitivity, modest increases in growth, and decreases in weight gain on HFD
In human beings, the maintenance of reduced body weight is achieved via coordination of metabolic, neuroendocrine, and autonomic responses that normally favor weight regain following a loss [40]