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anche farmaci consolidati, come linsulina e diversi medicinali contro diabete e obesit, appartengono a questa grande famiglia

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The mechanism behind this is still unclear, although mutations in ubiquitin-specific protease 8 ( USP8 ), a deubiquitinase enzyme with various targets including EGFR, leading to hyperactivation of this enzyme and subsequent increased EGFR deubiquitination and recirculation to the cell surface, enhance the release of ACTH (147,150)