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Together, these observations further support that DMF mediates gene locus-specific regulatory mechanism in an NRF2, DNA hydroxymethylation dependent or both to produce protective effect against ferroptosis in SCD

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ROS and reactive nitrogen species (RNS) are well recognized for playing a dual role as both deleterious and beneficial species, since they can be either harmful or beneficial to living systems [1012]

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In contrast to other proteins that do not engage FcRn, the two ligands are prevented from progressing to the lysosomes for degradation by binding to the receptor in early sorting endosomes 41,43,47,49,50

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doi: 10.1007/s00702-011-0763-x 225 KanchanatawanBSirivichayakulSThikaSRuxrungthamKCarvalhoAFGeffardMet al

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