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relatively large apparent volume of distribution of ~2-3 L/kg in horse, cows, sheep & dogs reflecting its relatively high lipid solubility in dogs, xylazine is metabolized by the liver to ~20 metabolites, with only 8% eliminated unchanged in the urine, (Rector et al, 1996

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11 GSH depletion and the subsequent low stores of protein thiol result in both calcium release from intracellular stores and inhibition of calcium extrusion, producing a marked increase in cytosolic calcium concentration, which triggers cytotoxicity

The rats were divided into four groups, one receiving ultrasound-mediated insulin delivery and the others receiving subcutaneous insulin at different doses (0.15, 0.20, and 0.25 U/kg)

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