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In a meta-analysis of patients with acute relapse or first onset schizophrenia, levels of peripheral pro-inflammatory cytokines including IL-6, IL-1, and IFN- were significantly decreased after antipsychotic treatment compared to baseline.128 Those results are in line with previous studies reporting that both typical and atypical antipsychotics suppress microglial activation, thus inhibiting inflammatory mediators.129130131132133 Antipsychotics also enhance neurogenesis

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2026;DOI:10.1016/S0140-6736(26)00202-3

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Semaglutide has a terminal half-life of approximately 1 week (about 7 days or 168 hours), according to FDA prescribing information