Vulnerable populations such as frail patients, pregnant women, adolescents and the elderly may be more susceptible to adverse effects like muscle loss or nutritional deficits
Similar to GIP, the stimulatory effects of GLP-1 on insulin expression and secretion were observed in the presence of high (450 mg/dL) but not normal (99 mg/dL) concentrations of glucose in the cultured cells, indicating the glucose-dependent insulinotropic effect of GLP-1 (117)
116 ShenF.YangW.LuanG.PengJ.LiZ.GaoJ.et al (2024)
Martin CMA, Irwin N, Flatt PR, Gault VA (2013) A novel acylated form of (d-Ala(2))GIP with improved antidiabetic potential, lacking effect on body fat stores
The regulatory picture matters enormously here, and it is frequently blurred by vendor copy: Cosmetic ingredient
These findings indicate that lactate directly or indirectly weakens NK cell-mediated tumor immune surveillance