While retinoids thicken the dermis through collagen stimulation, recent research suggests that prescription-strength tretinoin may thin the epidermis over 12+ months of continuous use, as the forced turnover eventually leads to cellular compaction
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These changes are related to the sodium-retaining properties of GH and IGF-1 via ENaC in the renal distal tubules ( vide supra ) and can be reversed if patients undergo effective treatment of the GH-producing tumor [100]
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Food and Drug Administration) In short: the medical evidence does not support injecting glutathione for skin-lightening and there is significant evidence of harm or risk
