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Although the human relevance of these findings remains uncertain, as human C-cells have lower GLP-1 receptor expression compared to rodents, the potential risk necessitates avoiding this medication in patients with any personal or family history of medullary thyroid carcinoma

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In a multicellular organism, TLs are highly heterogeneous across different tissues and cell types depending, at least partly, on the tissue-specific proliferation rate, but they generally tend to decrease with age in all proliferating tissues (Demanelis et al., The size of critically short (uncapped) telomeres may be stabilized by telomerase, a reverse transcriptase enzyme that can elongate chromosome ends de novo

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