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The GHK-Cu complex adopts a square-planar geometry, coordinated through the nitrogen atoms of the imidazole ring of histidine, the -amino group of glycine, and the deprotonated amide nitrogen of the glycine-histidine peptide bond

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Materials and Methods Cell Culture and Drug Treatments HCM, C2C12 and HUVEC were cultured in high-glucose DMEM (Gibco BRL, USA) supplemented with 5% fetal bovine serum (Gibco BRL, USA) without antibiotics in acceptable conditions (5% CO 2 , 37C)

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2009 RCT documented improvements in mottled hyperpigmentation alongside fine-wrinkle reduction in photoaged skin 10