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Altered functional coupling with peroxisomes and lipid droplets intensified oxidative stress, fatty-acid disequilibrium, and lipotoxic injury, particularly in metabolically unfavorable settings

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Phospholipid peroxy radicals are relatively unstable and can react with Fe 2+ , resulting in a chain expansion of phospholipid peroxidation, thus triggering ferroptosis signals (31, 32)

Immune function, cognitive performance, emotional regulation, metabolic health, and longevity are all downstream of quality sleep

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a Adjunct to lifestyle/behavioral intervention in all groups, with counseling, and diet and exercise recommendations