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This was compared to 3% weight loss in people who received a placebo

To help address this, dual incretins are being developed

The profound weight loss and anatomical changes also have significant effects on the uptake and pharmacokinetics of orally administered drugs (336, 337)

Nevertheless, because endogenous oxyntomodulin is currently not believed to play a major role in regulating metabolic processes (55), it seems unlikely that cleavage of oxyntomodulin by DPP-4 would be associated with significant effects under normal physiological circumstances

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