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CRF ligands display distinct affinity to CRF receptors with CRF binding preferentially to CRF 1 and with lesser affinity to CRF 2 (Hillhouse and Grammatopoulos, 2006), while Ucn 1 displays equal high affinity to both CRF 1 and CRF 2 and Ucn 2 and 3 are selective CRF 2 agonists (Grace et al., 2007)

JCI Insight 8 , e164921 (2023)

equolifaciens [70, 71]

It should be noted that race is inconsistently reported in lipedema literatureit is unclear if this is because lipedema is more prevalent in Caucasian people or if lipedema is under-recognized in other races (Eakin, 2023)

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On the other hand, the obvious strategy to increase GSH levels is its direct administration