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Neuroglia 6(1):4 Gargus M et al (2025) Mechanisms of vagus nerve stimulation for the treatment of neurodevelopmental disorders: a focus on microglia and neuroinflammation
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2.1.3.2 The GCH1/BH4/DHFR axis Guanosine triphosphate (GTP) cyclohydrolase 1 (GCH1) catalyzes the initial step in the biosynthesis of tetrahydrobiopterin (BH4), a process that also involves 6-pyruvyl tetrahydrobiopterin synthase (PTPS) and sepiapterin reductase (SPR)
These avenues promise to expand the reach, safety, and effectiveness of mRNA therapeutics in cancer care
