Incretins are gut-derived peptide hormones, primarily GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide), secreted after nutrient intake to enhance glucose-dependent insulin release from pancreatic cells
Image source: GLP-1s and Food Noise One of the interesting impacts of the GLP1 medications is the reduction of what is called food noise, also known as food-related intrusive thoughts or food preoccupation (Mozafariun 2025)
The future of retatrutide dosing: what clinical trials tell us The dose schedule is likely to evolve as more phase 3 data becomes available
TRIUMPH-4 reported in December 2025
These results, while promising, require confirmation in the ongoing Phase 3 programme before any conclusions about comparative efficacy can be drawn
My provider, Kristi, made me feel supported from day one, even when I experienced side effects early on