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The researchers found these cognitive deficits were correlated with the continued upregulation of inflammatory markers

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Two T1D-associated at-risk variants, rs11203203 and rs80054410, in another regulator of T cell activation and LYP interacting-molecule, UBASH3A , have been shown to increase mRNA expression in human primary CD4+ T cells, thereby reducing IL-2 production by inhibiting NF-B signaling (77, 78)

doi: 10.1016/j.neuron.2008.04.009

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