Common signs that suggest B12 supplementation may be necessary include: Numbness or tingling in hands and feet , which signals peripheral nerve involvement
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In these cases, injections improve laboratory markers and help resolve symptoms tied to deficiency, such as fatigue, anemia, and certain neurological issues
When you swallow a B12 pill, several steps have to work for it to be absorbed: stomach acid and the enzyme pepsin must release B12 from food or the supplement, the stomach must secrete a protein called intrinsic factor that binds to B12, and the B12-intrinsic factor complex must reach the ileum (the end of the small intestine) where it is finally absorbed
For weight management purposes specifically , B12 injections are not recommended unless an underlying deficiency is confirmed
