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For patients splitting doses: Mark the vial with the date of first puncture in permanent marker Count punctures if you're splitting doses inconsistently (e.g., splitting some weeks but not others) Discard at 28 days regardless of remaining volume If you see any cloudiness, color change, or particles, discard immediately even if within the 28-day window FAQ Can I split my Zepbound dose into two injections per week

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R., Radwan, P., Radwan, M., Barcz, E., Poski, R., Motak-Pochrzst, H., Banasik, M., Sobczyski, M., & Kunierczyk, P

J Biosci Bioeng

Some people experience 40-60% reduction in daytime burping just from this timing change

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