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In addition, background references (where appropriate) included menopause, estrogens, women, skin aging, natural products, phytochemicals, polyphenols, and/or combination(s) thereof (without a year-limit range)

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Studies have shown that various sea cucumber extracts can influence melanin production 25,40,41,42,43

It is not the whole puzzle

Is it because of individual variability

Nature (2009) 457(7227):31821