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Gamma-glutamylcysteine 636-58-8 -Glu-Cys Endogenous Metabolite Interleukin Related TNF Receptor AMPK Sirtuin STAT PI3K NF-B JAK p38 MAPK JNK Akt Apoptosis Ferroptosis Raw264.7 murine macrophages PC12 cells BV-2 cells dipeptide inflammatory bowel disease type 2 diabetes cadmium-induced neurotoxicity Alzheimer's disease cerebral ischemia/reperfusion injury neuropathy alcoholic liver disease Inhibitor inhibitor inhibit

Peer review Peer review information Nature Reviews Urology thanks Ralf Henkel, Sandro Esteves and Luca Boeri for their contribution to the peer review of this work

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These higher plasma levels of -endorphin may serve to the pathogenesis, as -endorphins in the CNS have insufficient inhibition on GnRH [151, 153]

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