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Methylene blue is used in photodynamic therapy (PDT), a medical treatment that uses light and a photosensitizing agent to destroy abnormal cells

In addition, chronic but not acute GSH depletion by buthionine sulfoximine (BSO) recapitulated the iron-induced phenotype

Maintaining adequate antioxidant capacity allows the body to adapt to physical stressors without tipping into prolonged fatigue or immune vulnerability

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Furthermore, the model predicts competition between radical-dependent and GSH-dependent GSSH reduction