The favorable results from the placebo-controlled FLOW trial, conducted with semaglutide 1.0 mg in patients with T2D and chronic kidney disesase (CKD), are about to be disclosed, while ongoing dedicated trials will further explore the effects of OW semaglutide 2.4 mg (NCT04889183) and tirzepatide (NCT05536804) on kidney function parameters in obese/overweight individuals at high risk of CKD progression regardless of T2D
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Among these, coumarin and L-leucine showed the highest test statistics and lowest p-values, indicating stronger group separation relative to other metabolites, while L-octanoylcarnitine and kaempferol exhibited more moderate but consistent differences
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