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Receptor interactions for the remaining residues within the N-terminal 11 amino acids of exendin-4 were similar to those formed by GLP-1, albeit overall interactions deeper within TM2, TM3, TM5, and ECL2 were generally less persistent, and those in TM1 and TM7 were more persistent (Figure 6, Supplemental Table 3, Supplemental Movie 1)

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Further, RNA-seq data from age-dependent microglia in GRN / mice indicated significant upregulation of lysosomal functions ( Ctsb ) and lipid transport ( Apoe ) genes 72

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[DOI] [PMC free article] [PubMed] [Google Scholar] 27.Newell-Price J, Bertagna X, Grossman AB, Nieman LK