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Contrave is contraindicated in patients with uncontrolled high blood pressure, a seizure disorder or history of seizures, current use of other bupropion-containing products (such as Wellbutrin), bulimia or anorexia nervosa, chronic opioid use or current use of opioid agonists like methadone or Suboxone, current use of MAO inhibitors, or known allergy to naltrexone, bupropion, or any component of Contrave

Garraway SM, Petruska JC, Mendell LM

Injectable GLP-1 medications generally reach higher peak plasma levels because of more complete bioavailability

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Specifically, the use of GLP-1RAs as a metabolic pretreatment before IVF/ICSI is increasing, though much of this remains off-label exploration (192, 193)