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Both the US Food and Drug Administration and European medical officials have also denied claims Ozempic could result in an increased risk of suicidal thoughts

Dulaglutide (Trulicity) achieves once-weekly dosing through a fusion protein strategy (linking the GLP-1 analogue to an IgG4 Fc fragment), producing a half-life of approximately 5 days and a Tmax of 24 to 72 hours 15

van der Hoek J, Waaijers M, van Koetsveld PM, Sprij-Mooij D, Feelders RA, Schmid HA, Schoeffter P, Hoyer D, Cervia D, Taylor JE, Culler MD, Lamberts SW, Hofland LJ

Endocrinology 2005

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