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Highmark July 2026 Formulary Overview: Prescription Drug Management Updates Beginning July 1, 2026, Highmark Pharmacy Services is updating its formulary for Commercial and Healthcare Reform members to support safe, effective, and cost-conscious prescription drug use

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143,144 The mutated IDH1 and IDH2 proteins are endowed with a novel ability to catalyze the reduction of -KG to generate a rare metabolite, 2-hydroxyglutarate (2-HG), while consuming NADPH

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This ACE inhibitory activity is further enhanced after gastrointestinal digestion, with peptides of low molecular weight fractions showing the highest ACE inhibitory activity [139]