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These conditions are heritable and highly polygenic, with heritability estimates based on twin studies ranging from 3972% [55, 56]

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The mechanistic chain begins with NF-kB, the master regulator of inflammatory gene expression

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Notably, treatment with Fer-1, a ferroptosis inhibitor, significantly alleviated pericyte injury ( postmortem striatal brain tissue from three patients with PD exhibited elevated FTH1 and IL-8 expression, closely recapitulating the transcriptional profile of microglia in the in vitro model

MCT1 is expressed widely in a variety of tissues, such as muscle, kidney, liver and heart (45)