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McDonald and her colleagues have designed a trial the Integrated Strategies for Breast Cancer Prevention and Interception in Elevated-Risk Women, or INSPIRE Study "to show that the drugs are actually causal for protection" against breast cancer, she says

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(Peptide Sciences) FOXO4 expression is increased in senescent cells, and interfering with FOXO4 via shRNA or peptide competition leads to apoptosis of those cells

These programs must be linked with cancer registries alongside electronic health records to enhance external validity for detecting seriously debilitating outcomes that are infrequently occurring

Commentary: The expanding benefits of GLP-1 medicines

doi: 10.1186/s12882-022-02890-9 100 MafraD.BorgesN