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Hagen TM, Liu J, Lykkesfeldt J, Wehr CM, Ingersoll RT, Vinarsky V, Bartholomew JC, Ames BN

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3 Although no studies have prospectively stratified patients by baseline A1C in evaluation of the A1C-lowering efficacy of a DPP-4 inhibitor or SGLT2 inhibitor, post-hoc subgroup analyses have shown that the efficacy of SGLT2 inhibitors is greater than that of DPP-4 inhibitors among patients with higher baseline A1C ( 8-8.5%), while patients with baseline A1C at the lower end of the spectrum ( 30 mL/min and clinical CV disease according to Diabetes Canada

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GLP-1 also has protective effects on the heart and brain, reduces inflammation and cell death, and plays a role in learning, memory, and behavior related to rewards and taste

Pancreatitis is rare and, in trial data, has not occurred at rates higher than placebo