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Eukaryotic cells also utilize several additional approaches, including ER-associated degradation (ERAD), lysosomal proteases, and 20S proteasome complex to remove the oxidized/degraded proteins (reviewed in Korovila et al., 2017

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Current research trends emphasize understanding detailed mechanistic pathways and establishing comprehensive safety parameters through extended laboratory studies

All safety monitoring occurs within the structured framework of the clinical trial, and any concerns should be reported through the trial's adverse event reporting process without delay

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