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The acquisition was performed in scheduled multiple reaction monitoring (MRM) mode

In other words, it is not a synthetic invention so much as a naturally occurring signaling molecule that researchers have tried to understand and, in places, to study therapeutically

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In some cases, injections may be given daily or several times per week at the beginning of therapy, and then the interval may be extended or switched to oral tablets once vitamin levels and symptoms improve

(1997) 273:C137885

There are important policy reasons why regulators take their time reviewing such products