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The expression of the Tfr1 protein was elevated by HT treatment, which also decreased the levels of Nrf2, SLC7A11, GPX4, and NQO1 proteins in HCT116 cells (Fig

For example, even in the case of AOAA, historically the most commonly used CBS inhibitor, concerns have repeatedly been raised about its severe off-target effects on other PLP-dependent enzymes (Whiteman et al., 2011

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