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Discussion Findings from this investigation indicate that eight weeks of supplementation with ALCA results in an increase in resting nitrate/nitrite in pre-diabetics, but does not promote significant changes in other metabolic or oxidative stress variables measured at rest or post meal

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The pivotal Phase 3 obesity trial (NCT06939296) enrolled 840 adults and achieved ~12% mean weight loss at 52 weeks with VCT220 120 mg and 160 mg, with mainly mild-to-moderate GI events and no hepatic safety signal

1 H-MRS data quality The mean glutamate CRLB percentages did not differ between healthy controls and patients (mean (SD) in % = 3.36 (1.02) in controls

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