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Background and methodology Prior studies have shown evidence that bariatric surgery can reduce the risk for obesity-related cancers
However, in isolated mouse hearts perfused with the sAC inhibitor KH7, we observed loss of cardioprotection with GLP-1(2836), but not GLP-1, as measured by LVDP at the end of the reperfusion (25.2 1.7 mmHg, n = 3, vs
This is evidenced by inconsistent recruitment of PINK1/Parkin to the mitochondria, overaccumulation of LC3-I and/or LC3-II, and insufficient fusion of mitochondria with lysosomes (Vaillant-Beuchot et al., 2021)
The GLP-1 class illustrates both ends of this spectrum within a single therapeutic area
Frontiers in clinical diabetes and healthcare , 4 , 1293926
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