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Clinical trial data consistently shows tirzepatide producing greater average weight loss than semaglutide, making this switch particularly relevant for patients whove plateaued, want stronger results, or havent responded adequately to semaglutide alone

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Binding of the ligand (GLP-1) or its analog on the extracellular side of the protein induces conformational changes that are sensed by the G-proteins on the cytoplasmic face - initiating a signaling cascade (see Figure 3 a and b)