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Neurotherapeutics 17(4):17961812 Wei Q et al (2024) Targeting non-classical autophagy-dependent ferroptosis and the subsequent HMGB1/TfR1 feedback loop accounts for alleviating solar dermatitis by Senkyunolide I

The disconnect between short plasma half-life and prolonged therapeutic effects observed in many studies supports tissue-level mechanisms extending beyond circulating peptide concentrations

Omega-3 fatty acids, found in fish oil and fatty fish, directly support anti-inflammatory pathways that synergize with peptide mechanisms

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Conclusions To summarize, the 68-week treatment with coadministered cagrilintide and semaglutide resulted in substantial and clinically meaningful weight loss in adults with overweight or obesity, significantly outperforming monotherapies and placebo (- 5.5% vs