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The controlled composition and sterile preparation allow the solution to be used in experimental protocols requiring high-purity solvent systems
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Dose Requirements and Consistency: Because of first-pass metabolism and enzymatic breakdown, oral forms may require higher nominal dosing or specialized carriers to approach comparable exposure to injectables
Williams Hematology, 6th edition
For this reason, PT-141 is generally avoided or used cautiously in men who have: Uncontrolled high blood pressure Significant cardiovascular disease A history of stroke or severe heart conditions Men who were unable to tolerate sildenafil, Cialis, or other phosphodiesterase inhibitors due to blood pressure concerns may still be candidates for PT-141, but only after a thorough medical evaluation
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