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Peripherally derived bile acids primarily reflect hepatic metabolism and microbiota-dependent transformations, entering the CNS through passive diffusion (unconjugated species such as CA, CDCA, DCA) or active transport mediated by ASBT, OATP, and OST/ (conjugated species), thereby coupling central signaling to systemic metabolic states, circadian rhythms, and composition of intestinal microbiota [64,65,83]

Contraindications are similar to metformin: avoid with renal failure or severe liver disease

Severe or persistent vomiting, severe abdominal pain, fainting, dehydration, confusion, or symptoms of low blood sugar need prompt medical assessment, especially after a possible dosing error

doi: 10.1016/j.jacc.2022.11.005 2 MarxNHusainMLehrkeMVermaSSattarN

Sustained Loading : Continue the eccentric and strength training protocols for a minimum of 46 months

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