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and GSBR-1290, now in early Phase IIa evaluation

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15,392 In Wistar rats, a diet high in fat was found to lead to a decrease in the ratio of OPG/RANKL, which resulted in increased bone resorption and ultimately a reduction in bone mass

A small observational study published in JCI Insight (2022) examined individuals with obesity receiving semaglutide who reported reductions in alcohol intake, though the relationship to weight loss requires further investigation in controlled trials

SubQ has a bioavailability of 89% while the oral formulation is about 1%